Development of homology model for human Phosphodiesterase 3A has been targeted. Homology-modeling was utilized to generate a reliable molecular model of the human PDE3A based on the crystal structure of PDE3B using biopredicta module of Vlife MDS 4.3 and validated using online servers like procheck. In this work, developed a new homology model of human PDE3A enzyme and validated using various parameters like ramchandran plot and anolea plots which indicated that the developed model has good quality. Developed model of PDE3A can be useful for the development of novel human PDE3A inhibitors as potential vascular smooth muscle relaxants for treatment of various cardiovascular diseases.
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